{"id":53,"date":"2026-05-14T08:51:32","date_gmt":"2026-05-14T08:51:32","guid":{"rendered":"https:\/\/zunkelab.de\/?page_id=53"},"modified":"2026-05-14T13:54:21","modified_gmt":"2026-05-14T13:54:21","slug":"publications","status":"publish","type":"page","link":"https:\/\/zunkelab.de\/?page_id=53","title":{"rendered":"Publications"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"53\" class=\"elementor elementor-53\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b8bd4a5 e-con e-atomic-element e-flexbox-base e-c000fc5 \" data-id=\"b8bd4a5\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"b8bd4a5\">\n    \t\t<div class=\"elementor-element elementor-element-64ac931 elementor-widget elementor-widget-html\" data-id=\"64ac931\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<section class=\"publications-section\">\n\n  <div class=\"publications-heading-box\">\n    <span>Latest<\/span>\n    <h2>Publications<\/h2>\n  <\/div>\n\n  <div class=\"publications-grid\">\n\n    <div class=\"publication-card\">\n      <span class=\"publication-year\">2026<\/span>\n\n      <h4>\n        TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation\n      <\/h4>\n\n      <strong>\n        Bruno Ghirotto, Lu\u00eds Eduardo Gon\u00e7alves, Vivien Ruder, Christina James, et al.\n      <\/strong>\n\n      <p>\n        <em>Nature Communications<\/em>, 2026\n      <\/p>\n\n      <a href=\"https:\/\/www.nature.com\/articles\/s41467-026-71317-y\" target=\"_blank\" rel=\"noopener\">Article<\/a>\n    <\/div>\n\n    <div class=\"publication-card\">\n      <span class=\"publication-year\">2025<\/span>\n\n      <h4>\n        Recombinant cathepsins B and L promote \u03b1-synuclein clearance and restore lysosomal function in human and murine models with \u03b1-synuclein pathology\n      <\/h4>\n\n      <strong>\n        Balta D., Varghese A., Prieto Huarcaya S., et al., Zunke F.\n      <\/strong>\n\n      <p>\n        <em>Molecular Neurodegeneration<\/em>, 2025\n      <\/p>\n\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40883786\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n    <\/div>\n\n  <\/div>\n\n<\/section>\n\n<style>\n  .publications-section {\n    width: 100%;\n    max-width: 1120px;\n    margin: 34px auto 0;\n    display: grid;\n    grid-template-columns: 280px 1fr;\n    gap: 24px;\n    align-items: stretch;\n  }\n\n  .publications-heading-box {\n    background: linear-gradient(145deg, #071a33, #0b2344);\n    border: 1px solid rgba(190, 32, 45, 0.4);\n    border-radius: 22px;\n    padding: 28px;\n    color: #ffffff;\n    box-shadow: 0 14px 35px rgba(0, 0, 0, 0.25);\n    min-height: 100%;\n    display: flex;\n    flex-direction: column;\n    justify-content: center;\n  }\n\n  .publications-heading-box span {\n    color: #ff5a67;\n    font-size: 14px;\n    font-weight: 800;\n    letter-spacing: 0.12em;\n    text-transform: uppercase;\n    margin-bottom: 8px;\n  }\n\n  .publications-heading-box h2 {\n    margin: 0;\n    color: #ffffff;\n    font-size: 36px;\n    line-height: 1.05;\n    font-weight: 800;\n    letter-spacing: -0.04em;\n  }\n\n  .publications-heading-box::after {\n    content: \"\";\n    width: 70px;\n    height: 4px;\n    margin-top: 18px;\n    border-radius: 999px;\n    background: #be202d;\n  }\n\n  .publications-grid {\n    display: grid;\n    grid-template-columns: repeat(2, minmax(0, 1fr));\n    gap: 24px;\n  }\n\n  .publication-card {\n    background: linear-gradient(145deg, #071a33, #0b2344);\n    color: #ffffff;\n    border: 1px solid rgba(190, 32, 45, 0.35);\n    border-radius: 22px;\n    padding: 26px 28px;\n    box-shadow: 0 14px 35px rgba(0, 0, 0, 0.25);\n    min-height: 360px;\n    display: flex;\n    flex-direction: column;\n  }\n\n  .publication-year {\n    color: #ff5a67;\n    font-size: 13px;\n    font-weight: 800;\n    letter-spacing: 0.12em;\n    text-transform: uppercase;\n    margin-bottom: 14px;\n  }\n\n  .publication-card h4 {\n    margin: 0 0 16px;\n    color: #ffffff;\n    font-size: 20px;\n    line-height: 1.32;\n    font-weight: 750;\n  }\n\n  .publication-card strong {\n    display: block;\n    color: rgba(255, 255, 255, 0.82);\n    font-size: 15px;\n    line-height: 1.5;\n    margin-bottom: 12px;\n    font-weight: 600;\n  }\n\n  .publication-card p {\n    margin: 0 0 18px;\n    color: rgba(255, 255, 255, 0.76);\n    font-size: 15px;\n  }\n\n  .publication-card em {\n    color: #ff5a67;\n    font-style: italic;\n  }\n\n  .publication-card a {\n    display: inline-flex;\n    align-items: center;\n    justify-content: center;\n    width: fit-content;\n    margin-top: auto;\n    color: #ffffff;\n    background: #be202d;\n    padding: 9px 17px;\n    border-radius: 999px;\n    text-decoration: none;\n    font-size: 14px;\n    font-weight: 700;\n    transition: all 0.25s ease;\n  }\n\n  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elementor-element-fbfbc6c elementor-widget elementor-widget-html\" data-id=\"fbfbc6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<section class=\"research-focus-section\">\n\n  <div class=\"research-focus-text\">\n    <span>Research Focus<\/span>\n    <h2>Lysosomal pathways in neurodegeneration and much more...<\/h2>\n\n    <p>\n      Our research investigates how lysosomal dysfunction contributes to \u03b1-synuclein accumulation and neuronal vulnerability in Parkinson\u2019s disease.\n      By combining human disease models with molecular and cellular approaches, we aim to identify mechanisms that restore protein clearance and cellular homeostasis.\n    <\/p>\n  <\/div>\n\n  <div class=\"research-focus-image\">\n    <img decoding=\"async\" \n      src=\"https:\/\/zunkelab.de\/wp-content\/uploads\/2026\/05\/Neuron.png\" \n      alt=\"Fluorescence microscopy image of neuronal cells\"\n    >\n  <\/div>\n\n<\/section>\n\n<style>\n  .research-focus-section {\n    width: 100%;\n    max-width: 1120px;\n    margin: 34px auto;\n    display: grid;\n    grid-template-columns: 0.9fr 1.1fr;\n    gap: 26px;\n    align-items: stretch;\n  }\n\n  .research-focus-text {\n    background: linear-gradient(145deg, #071a33, #0b2344);\n    border: 1px solid rgba(190, 32, 45, 0.38);\n    border-radius: 24px;\n    padding: 34px;\n    color: #ffffff;\n    box-shadow: 0 18px 42px rgba(0, 0, 0, 0.28);\n    display: flex;\n    flex-direction: column;\n    justify-content: center;\n  }\n\n  .research-focus-text span {\n    color: #ff5a67;\n    font-size: 13px;\n    font-weight: 800;\n    letter-spacing: 0.12em;\n    text-transform: uppercase;\n    margin-bottom: 10px;\n  }\n\n  .research-focus-text h2 {\n    margin: 0 0 18px;\n    color: #ffffff;\n    font-size: 34px;\n    line-height: 1.08;\n    font-weight: 800;\n    letter-spacing: -0.04em;\n  }\n\n  .research-focus-text h2::after {\n    content: \"\";\n    display: block;\n    width: 74px;\n    height: 4px;\n    margin-top: 16px;\n    border-radius: 999px;\n    background: #be202d;\n  }\n\n  .research-focus-text p {\n    margin: 0;\n    color: rgba(255, 255, 255, 0.78);\n    font-size: 16px;\n    line-height: 1.65;\n  }\n\n  .research-focus-image {\n    position: relative;\n    border-radius: 24px;\n    overflow: hidden;\n    min-height: 340px;\n    border: 1px solid rgba(190, 32, 45, 0.38);\n    box-shadow: 0 18px 42px rgba(0, 0, 0, 0.28);\n    background: #071a33;\n  }\n\n  .research-focus-image::before {\n    content: \"\";\n    position: absolute;\n    inset: -1px;\n    background: radial-gradient(circle at 50% 50%, rgba(190, 32, 45, 0.28), transparent 48%);\n    z-index: 1;\n    pointer-events: none;\n  }\n\n  .research-focus-image::after {\n    content: \"\";\n    position: absolute;\n    inset: 0;\n    background:\n      linear-gradient(90deg, rgba(7, 26, 51, 0.5), rgba(7, 26, 51, 0.05)),\n      linear-gradient(180deg, rgba(7, 26, 51, 0.05), rgba(7, 26, 51, 0.25));\n    z-index: 2;\n    pointer-events: none;\n  }\n\n  .research-focus-image img {\n    width: 100%;\n    height: 100%;\n    min-height: 340px;\n    object-fit: cover;\n    object-position: center;\n    display: block;\n    filter: saturate(1.15) contrast(1.08) brightness(0.92);\n    transform: scale(1.01);\n    transition: transform 0.45s ease, filter 0.45s ease;\n  }\n\n  .research-focus-image:hover img {\n    transform: scale(1.055);\n    filter: saturate(1.25) contrast(1.12) brightness(0.98);\n  }\n\n  @media (max-width: 900px) {\n    .research-focus-section {\n      grid-template-columns: 1fr;\n    }\n\n    .research-focus-image,\n    .research-focus-image img {\n      min-height: 270px;\n    }\n  }\n\n  @media (max-width: 767px) {\n    .research-focus-section {\n      margin: 24px auto;\n      gap: 18px;\n    }\n\n    .research-focus-text {\n      padding: 24px;\n      border-radius: 18px;\n    }\n\n    .research-focus-text h2 {\n      font-size: 28px;\n    }\n\n    .research-focus-image {\n      border-radius: 18px;\n    }\n  }\n<\/style>\t\t\t\t<\/div>\n\t\t\n<\/div>\n<div class=\"elementor-element elementor-element-74595fa e-con e-atomic-element e-flexbox-base e-5ea506c \" data-id=\"74595fa\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"74595fa\">\n    \t\t<div class=\"elementor-element elementor-element-e036764 elementor-widget elementor-widget-html\" data-id=\"e036764\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<section class=\"other-publications-section\">\n\n  <div class=\"other-publications-heading\">\n    <span>Selected<\/span>\n    <h2>Other Publications<\/h2>\n  <\/div>\n\n  <div class=\"other-publications-list\">\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2023<\/div>\n      <div class=\"other-publication-content\">\n        <h4>Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models<\/h4>\n        <p><strong>Drobny A., Boros F. A., Balta D., Prieto Huarcaya S., et al., Zunke F.<\/strong><\/p>\n        <p><em>Translational Neurodegeneration<\/em>, 2023<\/p>\n        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37312133\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2022<\/div>\n      <div class=\"other-publication-content\">\n        <h4>The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches<\/h4>\n        <p><strong>Drobny A., Prieto Huarcaya S., Dobert J., Kluge A., et al., Zunke F.<\/strong><\/p>\n        <p><em>Biochimica et Biophysica Acta \u2013 Molecular Cell Research<\/em>, 2022<\/p>\n        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35217144\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2022<\/div>\n      <div class=\"other-publication-content\">\n        <h4>Detection of neuron-derived pathological \u03b1-synuclein in blood<\/h4>\n        <p><strong>Kluge A., Bunk J., Schaeffer E., Drobny A., et al., Zunke F.<\/strong><\/p>\n        <p><em>Brain<\/em>, 2022<\/p>\n        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35722765\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2021<\/div>\n      <div class=\"other-publication-content\">\n        <h4>Editorial: Intracellular Mechanisms of \u03b1-Synuclein Processing<\/h4>\n        <p><strong>Zunke F., Winner B., Richter F., Caraveo G.<\/strong><\/p>\n        <p><em>Frontiers in Cell and Developmental Biology<\/em>, 2021<\/p>\n        <a href=\"#\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2019<\/div>\n      <div class=\"other-publication-content\">\n        <h4>Modeling neuronopathic storage diseases with patient-derived culture systems<\/h4>\n        <p><strong>Zunke F., Mazzulli J. R.<\/strong><\/p>\n        <p><em>Neurobiology of Disease<\/em>, 2019<\/p>\n        <a href=\"#\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2018<\/div>\n      <div class=\"other-publication-content\">\n        <h4>Reversible Conformational Conversion of \u03b1-Synuclein into Toxic Assemblies by Glucosylceramide<\/h4>\n        <p><strong>Zunke F., Moise A. C., Belur N. R., et al.<\/strong><\/p>\n        <p><em>Neuron<\/em>, 2018<\/p>\n        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29290548\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n    <div class=\"other-publication-item\">\n      <div class=\"other-publication-year\">2017<\/div>\n      <div class=\"other-publication-content\">\n        <h4>The shedding protease ADAM17: Physiology and pathophysiology<\/h4>\n        <p><strong>Zunke F., Rose-John S.<\/strong><\/p>\n        <p><em>Biochimica et Biophysica Acta<\/em>, 2017<\/p>\n        <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28705384\/\" target=\"_blank\" rel=\"noopener\">PubMed<\/a>\n      <\/div>\n    <\/div>\n\n  <\/div>\n\n<\/section>\n\n<style>\n  .other-publications-section {\n    width: 100%;\n    max-width: 1120px;\n    margin: 34px auto 0;\n    background: linear-gradient(145deg, #071a33, #0b2344);\n    border: 1px solid rgba(190, 32, 45, 0.35);\n    border-radius: 24px;\n    padding: 32px;\n    color: #ffffff;\n    box-shadow: 0 14px 35px rgba(0, 0, 0, 0.25);\n  }\n\n  .other-publications-heading {\n    margin-bottom: 26px;\n  }\n\n  .other-publications-heading span {\n    display: block;\n    color: #ff5a67;\n    font-size: 13px;\n    font-weight: 800;\n    letter-spacing: 0.12em;\n    text-transform: uppercase;\n    margin-bottom: 8px;\n  }\n\n  .other-publications-heading h2 {\n    margin: 0;\n    color: #ffffff;\n    font-size: 34px;\n    line-height: 1.1;\n    font-weight: 800;\n    letter-spacing: -0.04em;\n  }\n\n  .other-publications-heading::after {\n    content: \"\";\n    display: block;\n    width: 74px;\n    height: 4px;\n    margin-top: 16px;\n    border-radius: 999px;\n    background: #be202d;\n  }\n\n  .other-publications-list {\n    display: flex;\n    flex-direction: column;\n    gap: 14px;\n  }\n\n  .other-publication-item {\n    display: grid;\n    grid-template-columns: 78px 1fr;\n    gap: 20px;\n    padding: 20px 0;\n    border-top: 1px solid rgba(255, 255, 255, 0.12);\n  }\n\n  .other-publication-item:first-child {\n    border-top: none;\n    padding-top: 0;\n  }\n\n  .other-publication-year {\n    color: #ff5a67;\n    font-size: 14px;\n    font-weight: 800;\n    letter-spacing: 0.1em;\n  }\n\n  .other-publication-content h4 {\n    margin: 0 0 9px;\n    color: #ffffff;\n    font-size: 18px;\n    line-height: 1.35;\n    font-weight: 750;\n  }\n\n  .other-publication-content p {\n    margin: 0 0 7px;\n    color: rgba(255, 255, 255, 0.78);\n    font-size: 14.5px;\n    line-height: 1.5;\n  }\n\n  .other-publication-content strong {\n    color: rgba(255, 255, 255, 0.86);\n    font-weight: 600;\n  }\n\n  .other-publication-content em {\n    color: #ff5a67;\n    font-style: italic;\n  }\n\n  .other-publication-content a {\n    display: inline-flex;\n    align-items: center;\n    width: fit-content;\n    margin-top: 6px;\n    color: #ffffff;\n    background: rgba(190, 32, 45, 0.95);\n    padding: 7px 14px;\n    border-radius: 999px;\n    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data-id=\"a3f5293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-nav_menu.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h5>Menu<\/h5><nav class=\"menu-publications-container\" aria-label=\"Menu\"><ul id=\"menu-publications\" class=\"menu\"><li id=\"menu-item-128\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-home menu-item-has-children menu-item-128\"><a href=\"https:\/\/zunkelab.de\/\">Welcome to Zunkelab!<\/a>\n<ul class=\"sub-menu\">\n\t<li id=\"menu-item-126\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-126\"><a href=\"https:\/\/zunkelab.de\/?page_id=50\">News<\/a><\/li>\n\t<li id=\"menu-item-127\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-127\"><a href=\"https:\/\/zunkelab.de\/?page_id=53\">Publications<\/a><\/li>\n\t<li id=\"menu-item-129\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-129\"><a href=\"https:\/\/zunkelab.de\/?page_id=55\">Our Reseach<\/a><\/li>\n<\/ul>\n<\/li>\n<li id=\"menu-item-160\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-160\"><a href=\"https:\/\/zunkelab.de\/?page_id=23\">Team<\/a><\/li>\n<li id=\"menu-item-222\" class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-222\"><a href=\"https:\/\/zunkelab.de\/?page_id=144\">Contact<\/a><\/li>\n<\/ul><\/nav>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7a9263 elementor-widget elementor-widget-html\" data-id=\"b7a9263\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<style>\n  .publication-card {\n    background: linear-gradient(145deg, #071a33, #0b2344);\n    color: #ffffff;\n    border: 1px solid rgba(190, 32, 45, 0.35);\n    border-radius: 18px;\n    padding: 24px 28px;\n    box-shadow: 0 14px 35px rgba(0, 0, 0, 0.28);\n    max-width: 720px;\n    min-height: 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9px 16px;\n    border-radius: 999px;\n    text-decoration: none;\n    font-size: 14px;\n    font-weight: 650;\n    transition: all 0.25s ease;\n  }\n\n  .publication-card a:hover {\n    background: #e13242;\n    transform: translateY(-2px);\n  }\n\n  @media (max-width: 767px) {\n    .publication-card {\n      min-height: auto;\n      padding: 22px;\n      border-radius: 16px;\n    }\n\n    .publication-card h4 {\n      font-size: 18px;\n    }\n  }\n<\/style>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Latest Publications 2026 TNF alpha unmasks enteric malate aspartate shuttle dysfunction bridging Parkinson disease and intestinal inflammation Bruno Ghirotto, Lu\u00eds Eduardo Gon\u00e7alves, Vivien Ruder, Christina James, et al. Nature Communications, 2026 Article 2025 Recombinant cathepsins B and L promote \u03b1-synuclein clearance and restore lysosomal function in human and murine models with \u03b1-synuclein pathology Balta D., [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/pages\/53","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/zunkelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=53"}],"version-history":[{"count":28,"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions"}],"predecessor-version":[{"id":252,"href":"https:\/\/zunkelab.de\/index.php?rest_route=\/wp\/v2\/pages\/53\/revisions\/252"}],"wp:attachment":[{"href":"https:\/\/zunkelab.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}